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Chemical Name: 1-Naphthylamine Hydrochloride
Synonyms: α-Naphthylamine hydrochloride, 1-Aminonaphthalene hydrochloride
CAS Number: 2381-85-3
Recommended Use: Intermediate in dye manufacturing, chemical research, laboratory reagent
Supplier Identification: Manufacturer or distributor contact details, emergency contact information
Classification: Acute toxicity (oral, dermal, inhalation), category 3; Skin sensitization, category 1; Carcinogenicity, category 1B; Specific target organ toxicity
Signal Word: Danger
Hazard Statements: Toxic if swallowed; may cause cancer; causes skin and eye irritation; may cause sensitization by skin contact
Pictograms: Skull and crossbones, Health hazard, Exclamation mark
Precautionary Statements: Avoid inhalation, use personal protective equipment, do not eat or drink while handling, store locked up, wash hands thoroughly after use
Substance: 1-Naphthylamine Hydrochloride
Purity: ≥98%
Chemical Formula: C10H9N·HCl
Molecular Weight: 179.65 g/mol
Impurities: May contain trace free HCl or related naphthyl compounds
Inhalation: Move person to fresh air, monitor for respiratory difficulties, administer oxygen or artificial respiration if breathing has stopped, seek immediate medical attention
Skin Contact: Remove contaminated clothing, rinse skin with soap and plenty of water for at least 15 minutes, seek medical advice if irritation persists
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes while keeping eyelids open, remove contact lenses, seek urgent medical assessment
Ingestion: Rinse mouth thoroughly, do not induce vomiting, provide water if subject is conscious, seek medical attention immediately
Advice for Physicians: Treatment is symptomatic and supportive; monitor for delayed symptoms related to carcinogenic or sensitizing properties
Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide
Specific Hazards: Emits toxic fumes under fire conditions including nitrogen oxides, hydrochloric acid, and carbon monoxide
Protective Equipment: Wear self-contained breathing apparatus with full facepiece and full protective gear
Specific Methods: Move unaffected containers away from fire area, cool exposed containers with water, contain run-off to prevent environmental contamination
Personal Precautions: Evacuate area, keep unprotected persons away, ventilate area, wear appropriate protective clothing including gloves and goggles
Environmental Precautions: Prevent from entering drains, watercourses, and soil; inform local authorities in case of environmental contamination
Methods for Containment and Cleaning Up: Use inert absorbent material for spills, shovel up into labeled disposal containers, wash spill area with water and detergent, ventilate until thorough decontamination
Precautions for Safe Handling: Avoid contact with skin, eyes, and clothing, avoid inhalation of dust or particles, work in well-ventilated or extracted areas, use local exhaust ventilation
Safe Storage Conditions: Store in tightly closed containers, away from incompatible materials such as oxidizers and acids, store in cool, dry, well-ventilated areas, segregate from food and drink
Specific End Use(s): Laboratory reagent, intermediate for industrial synthesis, handle only by trained personnel
Exposure Limits: OSHA PEL: 0.1 mg/m³; ACGIH TLV: 0.1 mg/m³ (as 1-naphthylamine)
Engineering Controls: Fume hood, local exhaust ventilation, eyewash stations, and safety showers
Personal Protective Equipment: Chemical-resistant gloves, laboratory coat, tightly fitting goggles, NIOSH-certified respirator if airborne exposure is possible, avoid open skin exposure
Appearance: Crystalline powder or flakes, white to pale yellow
Odor: Slightly aromatic or amine-like scent
pH: Not available (aqueous solution may be acidic)
Melting Point: 245°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Soluble in water and ethanol, sparingly soluble in ether
Flash Point: Not applicable
Vapor Pressure: Negligible
Density: 1.241 g/cm³
Partition coefficient (log Kow): Estimated 1.46
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts with strong oxidizing agents, acids, and acid chlorides
Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide
Conditions to Avoid: Heat, open flames, moisture, incompatible substances
Polymerization: Will not occur under normal handling
Acute Toxicity: Oral LD50 (rat): ~200 mg/kg
Skin Corrosion/Irritation: Causes skin irritation, prolonged contact may cause dermatitis
Serious Eye Damage/Irritation: Causes severe eye irritation
Respiratory or Skin Sensitization: Known to cause allergic skin sensitization
Carcinogenicity: Classified as a Group 2A carcinogen by IARC; NTP and OSHA list as possible human carcinogen
Mutagenicity: Positive in bacterial and mammalian cell assays
Chronic Toxicity: Prolonged exposure may cause bladder cancer, hematuria, and anemia; cumulative effects possible after chronic exposure
Toxicity to Aquatic Life: Harmful to aquatic organisms, long-term adverse effects possible in aquatic environments
Persistence and Biodegradability: Not readily biodegradable, persistent in water and soil
Bioaccumulative Potential: Moderate, may accumulate in aquatic food chains
Mobility in Soil: Limited mobility due to moderate water solubility
Other Adverse Effects: Avoid environmental release, significant spills may require environmental remediation
Waste Treatment Methods: Dispose of as hazardous waste in accordance with federal, state, and local regulations
Contaminated Packaging: Decontaminate containers before disposal or use licensed hazardous waste contractor
Special Precautions: Do not discharge to sewer system, avoid incineration without emission controls
Recommended Disposal: Use chemical incinerator equipped with afterburner and scrubber, consult local environmental authorities
UN Number: 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains 1-Naphthylamine Hydrochloride)
Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Transport Labels: Toxic, keep away from foodstuffs and animal feed
Special Transport Precautions: Avoid exposure during transport, use sealed and labeled containers, check for transport-specific national or international regulations
OSHA: Regulated hazardous substance under OSHA Hazard Communication Standard
TSCA: Listed in the Toxic Substances Control Act inventory
SARA 313: Listed as a toxic chemical subject to reporting requirements
CERCLA: No established reportable quantity
California Proposition 65: Listed as known to the State of California to cause cancer
Europe REACH: Subject to authorization and restrictions; may require registration for import or manufacture
Other International Regulations: Subject to workplace exposure limits and environment protection controls in multiple jurisdictions
