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Product Name: 1-Naphthyl Isothiocyanate
Synonyms: α-Naphthyl isothiocyanate, Naphthalene-1-isothiocyanate
CAS Number: 86-57-7
Molecular Formula: C11H7NS
Molecular Weight: 185.25 g/mol
Recommended Use: Research, chemical synthesis, pharmaceutical intermediate
Supplier: Laboratory chemical distributor
Contact Information: Emergency contact phone listed on product label
Classification: Acute Toxicity (Oral), Skin Irritant, Eye Irritant, Respiratory Sensitizer
Signal Word: Danger
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause allergy or asthma symptoms, suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure.
Pictograms: Skull and crossbones, Health hazard, Exclamation mark
Precautionary Statements: Do not breathe dust or vapors, wash hands thoroughly after handling, avoid release to the environment, use only outdoors or in well-ventilated area, wear protective gloves and eye protection. Seek medical advice if feeling unwell.
Chemical Name: 1-Naphthyl Isothiocyanate
Concentration: ≥98% by weight
Impurities: None identified in significant quantities; minimal unreacted naphthalene or residual solvents may be present.
Other Components: This product consists essentially of pure 1-naphthyl isothiocyanate.
Inhalation: Remove person to fresh air, assist breathing with oxygen if needed, get immediate medical attention for persistent symptoms.
Skin Contact: Remove contaminated clothing, rinse skin with running water for at least 20 minutes, wash area with soap, seek medical attention if irritation continues.
Eye Contact: Rinse eyes slowly and gently with water for at least 15 minutes, keep eyelids apart, remove contact lenses if possible, get medical attention fast.
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical advice at once.
Acute and Delayed Effects: Irritation, respiratory discomfort, risk of allergic reaction, potential for delayed toxicity. Medical attention recommended in all exposure cases.
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray on surrounding materials
Specific Hazards: Emits toxic fumes of nitrogen oxides, sulfur oxides, carbon monoxide under fire conditions, combustion can cause hazardous vapors
Protective Equipment: Firefighters use self-contained breathing apparatus and protective gear
Advice for Firefighters: Move containers from fire area only if safe, use water mist to cool containers, avoid inhaling smoke and combustion products.
Personal Precautions: Evacuate unprotected personnel, avoid inhalation and skin contact, use personal protective equipment including gloves, mask, goggles.
Environmental Precautions: Prevent entry into drains, surface water, or soil.
Methods for Clean Up: Clean up spills with inert absorbent material, collect and place in waste container for disposal, ventilate area, wash exposed surfaces thoroughly.
Small Spill: Scoop up carefully, avoid dust generation, clean area with detergent.
Large Spill: Dike area, use specialized trained personnel.
Precautions for Handling: Use in chemical fume hood, avoid breathing vapors or dust, avoid contact with skin and eyes, wash hands after use.
Safe Storage Conditions: Store in tightly closed container in a cool, dry, well-ventilated place away from incompatible substances like strong acids, bases, and oxidizers.
Incompatible Materials: Strong acids, bases, oxidizers, moisture, heat sources
Other Requirements: Label containers clearly, restrict access to trained personnel, store away from foodstuffs.
Occupational Exposure Limits: No established limit for this compound; handle as hazardous chemical
Engineering Controls: Use chemical fume hood, local exhaust ventilation
Respiratory Protection: Approved dust or vapor respirator where risk of exposure exists
Skin Protection: Chemical-resistant gloves (nitrile, neoprene), laboratory coat
Eye Protection: Chemical safety goggles
Other Controls: Safety shower and eyewash in work area, practice good personal hygiene, do not eat or drink in handling area
Appearance: White to off-white crystalline powder
Odor: Pungent, characteristic isothiocyanate smell
Odor Threshold: Not established
pH: Not applicable
Melting Point: 59–63°C
Boiling Point: Decomposes
Flash Point: >110°C
Evaporation Rate: Not available
Flammability: Not easily flammable, may burn at high temperature
Vapor Pressure: Low
Vapor Density: Not determined
Solubility: Insoluble in water, soluble in organic solvents like acetone, ethanol, ether
Partition Coefficient (n-octanol/water): Not measured
Autoignition Temperature: Not determined
Decomposition Temperature: Above melting point
Viscosity: Not applicable (solid)
Chemical Stability: Stable under standard conditions, sensitive to moisture and strong light
Reactivity: May react with strong acids, bases, oxidizers
Possibility of Hazardous Reactions: Risk of hazardous fumes on combustion
Conditions to Avoid: Heat, moisture, direct sunlight, open flames
Incompatible Materials: Acids, alkalis, oxidizing substances
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide, isothiocyanate vapors
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Acute Toxicity: LD50 (oral, rat): 490 mg/kg
Skin Corrosion/Irritation: Causes mild to moderate irritation, risk of dermatitis
Serious Eye Damage/Irritation: Causes conjunctival redness, pain
Sensitization: May trigger respiratory and skin sensitization in some individuals
Germ Cell Mutagenicity: No clear data
Carcinogenicity: Animal studies suggest possible carcinogenicity, not listed by IARC or NTP
Reproductive Toxicity: Insufficient data
Target Organ Toxicity: Liver, kidneys, respiratory tract
Other Health Effects: Cough, headache, dizziness, long-term exposure may impair organ function
Ecotoxicity: Harmful to aquatic life, limited biodegradability
Persistence and Degradability: Persistent, may not readily degrade in environment
Bioaccumulative Potential: Potential for bioaccumulation in aquatic organisms
Mobility in Soil: Binds to soil, not highly mobile
Other Adverse Effects: Risk of soil and water contamination, not expected to cause significant atmosphere effects
Disposal Methods: Dispose by incineration in accordance with local laws, chemical waste program required, do not release into sewers or natural water.
Contaminated Packaging: Must be handled as hazardous waste; rinse and dispose according to regulations
Other Recommendations: Work with certified waste disposal contractor, document waste generation and transport
UN Number: Not regulated for transport above small-scale laboratory amounts
Proper Shipping Name: 1-Naphthyl Isothiocyanate
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Environmental Hazards: Marine pollutant if spilled in large quantity
Special Precautions: Secure packaging, labeling per local and international transport law, keep containers sealed and upright during transport
TSCA Status: Listed
REACH Registration: Exempted or pre-registered for EU research use
SARA Title III: Not listed as hazardous, but R&D use demands caution
California Proposition 65: Not currently listed
OSHA Hazard Communication: Chemical identified as hazardous, requires labeling and SDS availability to employees
Canadian WHMIS Classification: D2B - Toxic Material Causing Other Toxic Effects
Other Regulation: Always check local, regional, and national regulations before use and disposal, report accidental environmental release if mandated
