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Product Name: 1-Bromo-3-Methylbutane
Chemical Formula: C5H11Br
CAS Number: 107-82-4
Synonyms: Isoamyl Bromide, 3-Methyl-1-Bromobutane
Recommended Use: Organic Synthesis, Pharmaceutical Intermediate, Research and Development
Supplier: Chemical supply companies dealing in specialty organics
Contact Information: Refer to supplier documentation for emergency contact numbers
Emergency Number: Local poison control or fire emergency service
GHS Classification: Flammable Liquids (Category 3), Acute Toxicity (Oral, Category 4), Serious Eye Irritation (Category 2A), Skin Irritation (Category 2)
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor; Harmful if swallowed; Causes skin irritation; Causes serious eye irritation
Pictograms: Flame, Exclamation Mark
Potential Health Effects: Inhalation may lead to respiratory irritation, coughing, or drowsiness. Eye and skin contact can cause irritation, redness, or burns. Ingestion can trigger nausea, vomiting, abdominal pain, or toxicity.
Environmental Hazards: Harmful to aquatic life with long lasting effects. Runoff may contaminate waterways or ground water sources in high concentrations.
Chemical Identity: 1-Bromo-3-Methylbutane
CAS No: 107-82-4
Purity/Concentration: > 99% typical in laboratory and manufacturing supply
Impurities: No hazardous impurities anticipated above reportable thresholds
Stabilizers or Additives: Not intentionally present in most pure product lots
Inhalation: Move exposed individual to fresh air immediately. Ensure clear airways and seek medical advice if symptoms persist, such as respiratory distress or dizziness.
Skin Contact: Wash thoroughly using soap and water. Remove contaminated clothing and wash before reuse. Seek medical care for persistent rash, blistering, or chemical burns.
Eye Contact: Rinse cautiously with plenty of water for at least 15 minutes. Remove contact lenses if present and easy to do so. Immediate medical attention is strongly recommended.
Ingestion: Do not induce vomiting unless directed by medical personnel. Rinse mouth with water if the person is conscious. Get emergency medical help right away.
Notes for Physician: Treat symptoms and provide supportive care. There is no specific antidote, but observation for respiratory and dermal effects is necessary.
Extinguishing Media: Use dry chemical, foam, carbon dioxide (CO2), or water spray. Do not use direct water jets on burning liquid.
Specific Fire Hazards: Vapors can form explosive mixtures with air, particularly in confined spaces. In case of fire, hazardous combustion products such as hydrogen bromide, carbon oxides may arise.
Protective Gear: Firefighters must wear self-contained breathing apparatus and full protective gear.
Firefighting Instructions: Move containers from fire area if safe. Cool closed containers with water. Control run-off to prevent environmental contamination. Avoid inhalation of toxic vapors.
Spill Response: Evacuate personnel to safe areas and provide adequate ventilation. Wear suitable personal protective equipment (including gloves, goggles, and respiratory protection).
Containment: Prevent further leakage or spillage by diking area with non-combustible material. Do not allow material to enter drains or waterways.
Clean-up Methods: Absorb spilled material with inert absorbent (sand, earth, vermiculite). Place in chemical waste container for proper disposal.
Decontamination: Wash spill site thoroughly once cleanup is complete. Dispose of contaminated materials according to local regulations.
Notification: Report larger releases to appropriate authorities as mandated by local, state, or federal law.
Handling: Work in a well-ventilated, chemical fume hood environment. Avoid inhalation, ingestion, or contact with skin and eyes. Ground all equipment. Practice good hygiene after handling.
Storage: Store in tightly closed containers, away from heat sources, open flames, and direct sunlight. Keep in a cool, dry, and well-ventilated space. Segregate from oxidizing agents and strong bases.
Container Materials: Use glass, Teflon, or compatible plastic containers. Metal containers are typically avoided due to potential reactivity.
Storage Conditions: Store at ambient temperature, avoiding sources of ignition.
Engineering Controls: Use local exhaust ventilation or work inside a chemical fume hood to prevent exposure to vapors.
Eye Protection: Chemical safety goggles and, where possible, a face shield.
Skin Protection: Wear chemical-resistant gloves (nitrile or neoprene), long sleeves, and a lab coat.
Respiratory Protection: Use a NIOSH-approved air-purifying respirator for organic vapors if exposure is likely.
Work Practices: Wash hands thoroughly after handling and before eating or drinking. Do not smoke or use open flames where material is used.
Exposure Limits: No OSHA PEL or ACGIH TLV established for this compound. Use prudent practices and minimize exposure.
Appearance: Colorless to pale yellow liquid
Odor: Distinct, sharp, ether-like smell
Boiling Point: 119-121°C (246-250°F)
Melting Point: Below -80°C
Flash Point: 29°C (closed cup)
Autoignition Temperature: Not specifically determined in open literature
Explosion Limits: Not precisely known; vapors may form explosive mixtures with air
Density: Approximately 1.217 g/mL at 25°C
Solubility: Insoluble in water; soluble in organic solvents (ethanol, ether)
Vapor Pressure: 17 mmHg at 20°C
Partition Coefficient (log Kow): Around 2.8, indicating moderate hydrophobicity
Viscosity: Low; behaves as a mobile liquid
Chemical Stability: Stable under standard storage and handling conditions. Prolonged exposure to light, moisture, or high temperature may cause slow decomposition.
Reactive Incompatibilities: Reacts with strong oxidizers, strong bases, some metals and reducing agents, potentially producing hazardous decomposition products.
Decomposition Products: Hydrogen bromide, carbon monoxide, carbon dioxide. May emit toxic fumes on heating or burning.
Hazardous Polymerization: Not known to occur under normal conditions.
Other Concerns: Avoid sources of ignition, sparks, static discharge, and incompatibles to maintain safety in use and storage.
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Oral LD50 values in rats typically between 2000-5000 mg/kg. Inhalation can depress nervous system.
Skin and Eye Irritation: Can cause itching, redness, or burns if not washed away quickly.
Central Nervous System Effects: Dizziness, confusion, or depressive symptoms possible after significant inhalation.
Long-term Exposure: Studies are limited. Prolonged contact may result in dermatitis; repeated high exposures with experimental animals have shown mild organ effects.
Carcinogenicity/Mutagenicity: No classified as a carcinogen by IARC, ACGIH, NTP, or OSHA; no mutagenicity data established for this compound in mainstream sources.
Other Effects: Aspiration during ingestion or vomiting may cause chemical pneumonitis.
Aquatic Toxicity: Harmful to aquatic organisms; estimated LC50 (fish, 96h) > 10 mg/L
Persistence and Degradability: Not easily biodegradable. Expected to persist in soil or sediments if released.
Bioaccumulation Potential: Moderate; log Kow around 2.8 suggests potential for accumulation in aquatic life.
Mobility in Soil: Tends to adsorb to soil and organic matter; some risk of slow movement toward groundwater.
Other Adverse Effects: May disrupt aquatic environment balance at high concentrations; avoid uncontrolled discharge into surface or subterranean water sources.
Waste Disposal Method: Material should be collected and disposed of as hazardous waste, using a licensed chemical waste contractor.
Disposal Containers: Use approved, clearly labeled containers resistant to corrosion and leaks.
Incineration: Incinerate in a permitted site with adequate flue gas scrubbing to minimize release of hydrogen bromide or other toxic gases.
Do Not: Do not pour into sewer, ground, or open environment. Avoid disposal with regular household or municipal waste.
Contaminated Packaging: Rinse thoroughly with suitable solvent and dispose as hazardous waste; follow local or regional regulations.
UN Number: UN2345
Proper Shipping Name: 1-Bromo-3-Methylbutane
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: III
Marine Pollutant: Designation may apply depending on shipping concentrations and regulations
Labels: Flammable liquid symbol required
Special Precautions: Keep containers tightly sealed and upright. Separate from sources of ignition and incompatible cargo. Provide sufficient placarding for emergency response.
Regulatory Transport Codes: Subject to ADR/RID, IMDG, IATA/ICAO codes depending on mode under international shipping.
OSHA/TSCA Status: Listed as a chemical substance; manufacturers and users must comply with general chemical handling and safe workplace requirements.
SARA Title III (Sections 311/312): Classified under immediate health hazard, fire hazard.
REACH Status (EU): Included in the European inventory; importers and users in Europe should verify registration status and confirm any use restrictions.
California Proposition 65: Not listed on known carcinogens or reproductive hazards by California standards, based on available data.
Canadian DSL/NDSL: Listed; uses in Canada require compliance with WHMIS for flammable substances.
Other National/International Regulations: Local authorities may list further requirements, so users should verify their specific obligations by jurisdiction.
