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Product Name: 1-Bromo-2-Methylpropane
Chemical Formula: C4H9Br
Synonyms: Isobutyl bromide, Isobromobutane
CAS Number: 78-77-3
Recommended Use: Laboratory reagent, intermediate in organic synthesis
Manufacturer Information: Provided by supplier or manufacturer, check product label for emergency phone number and address
Emergency Contact: Chemtrec, 24-hour response team, numbers available on most labels for North America and international shipments
GHS Classification: Flammable liquids (Category 3), Acute toxicity, oral (Category 4), Skin irritation (Category 2), Eye irritation (Category 2A), Specific target organ toxicity, single exposure (Category 3)
Pictograms: Exclamation mark, Flame
Signal Word: Warning
Hazard Statements: Causes skin irritation, causes serious eye irritation, may cause respiratory irritation, harmful if swallowed
Precautionary Statements: Avoid breathing vapors or mists, wear protective gloves and eye protection, use only in well-ventilated areas, wash skin thoroughly after handling, store away from heat sources and open flames
Chemical Name: 1-Bromo-2-Methylpropane
Concentration: ≥99.0%
Impurities: Trace amounts of 2-bromobutane, 1-chlorobutane, moisture (less than 1% combined), may include proprietary stabilizers
Other Components: No significant non-hazardous components indicated by the supplier
Inhalation: Move to fresh air, keep person at rest, get medical attention if symptoms like coughing or dizziness persist, provide oxygen if breathing is difficult
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water, wash using mild soap, seek medical attention for persistent irritation
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, keep eyelids open, remove contact lenses if present and easy to do, seek medical help if irritation develops
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical advice immediately, never give anything by mouth to an unconscious person
Most Important Symptoms and Effects: Eye and skin irritation, possible respiratory tract discomfort, gastrointestinal symptoms if ingested
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol foam, water spray (for cooling containers only, not direct flame fighting)
Unsuitable Extinguishing Media: Full water jet can spread the fire
Specific Hazards: Vapors may form explosive mixtures with air, combustion produces toxic and corrosive gases including hydrogen bromide, carbon monoxide, carbon dioxide
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear, avoid inhalation of combustion products
Special Precautions: Cool unopened containers with water spray, remove containers from fire area if safe to do so, limit spread of spilled material and contaminated water runoff
Personal Precautions: Evacuate unnecessary personnel, avoid inhalation and skin contact, use personal protective equipment including gloves and goggles
Methods for Cleanup: Ventilate the area, contain and absorb spill using inert materials like vermiculite or sand, collect in suitable containers for disposal, avoid direct release to environment
Environmental Precautions: Prevent entry into waterways, drains, or sewers, notify authorities if large spills occur and environmental contamination is likely
Decontamination Methods: Wash spill area with detergent and large volumes of water after cleanup is complete
Safe Handling: Handle in a chemical fume hood or well-ventilated area, avoid contact with skin, eyes, and clothing, do not breathe vapors
Hygiene Practices: Wash hands and face thoroughly after working with product, remove and wash contaminated clothing before reuse, keep food and drink away from work area
Storage Requirements: Store in tightly closed original container, keep away from direct sunlight, heat, sources of ignition, acids, and strong oxidizers, recommended storage temperature is room temperature, away from moisture
Incompatibilities: Bases, strong oxidizing agents, powdered metals, may react violently with sodium or potassium
Exposure Limits: No specific OSHA, NIOSH, or ACGIH exposure limits established for 1-Bromo-2-Methylpropane, keep airborne concentrations as low as reasonably achievable
Engineering Controls: Use local exhaust ventilation or fume hood to control exposure, provide eyewash stations and safety showers in work area
Personal Protective Equipment: Nitrile or neoprene gloves, chemical splash goggles, laboratory coat, in case of high vapor or aerosol concentration use NIOSH-approved respirator
Environmental Controls: Avoid uncontrolled release to water systems or soil, use closed systems or suitable containment during transfer
Appearance: Colorless liquid
Odor: Slightly sweet, ether-like solvent odor
Odor Threshold: No data available
Boiling Point: 91–93°C (196–199°F)
Melting Point: -119°C (-182°F)
Flash Point: 19°C (66°F) (closed cup)
Evaporation Rate: Not determined but expected to be moderately fast
Flammability: Flammable liquid
Upper/Lower Flammability or Explosive Limits: Lower: 1.3%, Upper: 6.4% (estimates)
Vapor Pressure: 38 mm Hg at 25°C
Vapor Density: Approx. 4.1 (air=1)
Solubility: Insoluble in water, soluble in organic solvents (ether, alcohol)
Partition Coefficient (n-octanol/water): log Kow ~2.5
Decomposition Temperature: No reliable data, decomposes at high temperatures producing toxic gases
Density: 1.209 g/cm³ at 20°C
Viscosity: Not available
Chemical Stability: Stable under recommended storage and handling conditions
Possible Hazardous Reactions: Violent reaction with strong oxidizers, contact with alkali metals forms explosive products, risk of vapor-phase explosion with air
Conditions to Avoid: Heat, flame, sources of ignition, strong sunlight, moisture, and incompatibles
Materials to Avoid: Strong bases, powerful oxidizing agents, alkali metals including sodium and potassium
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen bromide, possible phosgene under severe fire conditions
Acute Toxicity: Oral LD50 (rat): varies between 800–1200 mg/kg, inhalation LC50 and dermal LD50 data not found but toxicity considered moderate
Skin Corrosion/Irritation: Produces redness and discomfort, can cause dermatitis with prolonged exposure
Serious Eye Damage/Irritation: Irritates eyes, causes tearing and redness
Respiratory or Skin Sensitization: May cause respiratory irritation, skin sensitization typically not reported
Repeated Dose Toxicity: Not well studied, caution recommended
Germ Cell Mutagenicity: Not classified based on available data
Carcinogenicity: Not listed by NTP, IARC, or OSHA
Reproductive Toxicity: Insufficient data
STOT – Single Exposure: May cause temporary central nervous system effects (dizziness, headache) if inhaled in high concentrations
Ecotoxicity: Toxic to aquatic life, LC50 (fish, 96 hr): estimated range 25–40 mg/L
Persistence and Degradability: Not readily biodegradable, persists in soil and water, slow to degrade under natural conditions
Bioaccumulative Potential: May accumulate in aquatic organisms based on log Kow value
Mobility in Soil: Moderate mobility, can leach into groundwater if not contained
Other Adverse Effects: Limited studies but vapor may contribute to urban smog formation, product should be kept from entering drains or natural water bodies
Safe Disposal Methods: Incinerate in a chemical incinerator equipped with afterburner and scrubber, follow local, regional, and national regulations; do not discharge to sewer or surface water
Contaminated Packaging: Containers should be triple rinsed, punctured or destroyed, managed as hazardous waste
Precautions: Wear suitable protective gear when handling waste, do not mix with incompatible materials in waste containers
Regulatory Obligations: Consult regulations for hazardous waste under RCRA or equivalent, observe labeling and manifest requirements
UN Number: UN2345
UN Proper Shipping Name: 1-Bromo-2-Methylpropane
Transport Hazard Class(es): 3 (Flammable liquid)
Packing Group: II
Labels: Flammable Liquid
Special Precautions: Keep containers tightly closed, segregate from strong oxidants and sources of ignition during transport
Emergency Response Guide Number: 128
Marine Pollutant: Not specifically listed but spill response should prevent direct contact with water bodies
OSHA: Not specifically regulated as a standalone substance, covered under general chemical hazard communication requirements
SARA Title III (EPCRA): Not listed as a Section 302 extremely hazardous substance, reportable under Section 311/312 for fire, sudden release, and acute health hazards; not listed under Section 313
TSCA: Substance appears on the TSCA inventory
EINECS/ELINCS (EU): Listed (201-205-5)
REACH: May require registration for significant quantities used in the EU
Canada DSL/NDSL: Listed in DSL
California Proposition 65: Not listed as a carcinogen or reproductive toxin
Other Restrictions: Local restrictions on storage and use of flammable and toxic chemicals may apply, always reference the latest regional chemical safety regulations and product safety guidance
