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Product Name: 1-(4-Aminophenyl)-4-(4-Hydroxyphenyl)Piperazine
Synonyms: NA
Recommended Use: Synthetic intermediate for pharmaceuticals
Supplier Information: Provided on purchase document
Emergency Contact: Refer to company safety hotline
CAS Number: 537761-69-2
UN Number: Not classified as hazardous for transport
REACH Registration: Not required for this intermediate
Classification: Eye irritation (Category 2), Skin sensitizer (Category 1B), Acute toxicity oral (Category 4)
Label Elements: Signal word: Warning; Hazard pictograms: Exclamation mark
Hazard Statements: Causes serious eye irritation, harmful if swallowed, may cause an allergic skin reaction
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, wear protective gloves and eye protection
Other Hazards: Dust formation possible, possible environmental hazard if spilled in large quantities
Chemical Name: 1-(4-Aminophenyl)-4-(4-Hydroxyphenyl)Piperazine
CAS Number: 537761-69-2
Concentration: >97% (as active ingredient)
Impurities: Typical synthesis byproducts <3% total, not classified as hazardous under GHS
Molecular Formula: C16H19N3O
Molecular Weight: 269.34 g/mol
Inhalation: Move to fresh air at once, monitor for breathing difficulties, seek medical attention if irritation persists
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, seek medical attention if rash or irritation develops
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, keep eyelids apart, remove contact lenses, call a doctor
Ingestion: Rinse mouth, drink water if conscious, do not induce vomiting, call poison control or physician for further guidance
Most Important Symptoms: Redness, burning or irritation of eyes and skin, possible headache and nausea after ingestion or inhalation
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide
Unsuitable Media: Do not use water jet, as this may spread fire
Special Hazards: Toxic fumes possible including carbon monoxide, nitrogen oxides, and various organic vapors
Protective Equipment for Firefighters: Wear self-contained breathing apparatus, full protective clothing including gloves and chemical suit
Advice: Move containers from fire area if it can be done safely, cool exposed containers with water spray to prevent rupture, avoid inhaling smoke
Personal Precautions: Keep unprotected persons away, ventilate area, use personal protective equipment including mask, gloves, and goggles
Environmental Precautions: Prevent release into waterways, drains, and soil
Methods for Containment and Cleanup: Cover spill with inert absorbent such as sand or vermiculite, collect in sealable container, wash area with soap and water, dispose of waste according to local regulations
Notification Procedures: Notify local environmental authorities if large quantities have entered environment
Handling: Handle in fume hood, avoid dust generation, use tools and containers that prevent spills, wash hands thoroughly after use
Storage Conditions: Store in cool, well-ventilated area, keep container tightly closed, protect from moisture and light
Incompatible Materials: Strong oxidizers, acids, and bases
Specific End Uses: Intermediate for pharmaceutical synthesis, lab-scale research
Control Parameters: No occupational exposure limit established, minimize exposure with local exhaust ventilation
Engineering Controls: Use chemical fume hood, explosion-proof exhaust where dust may form
Personal Protection: Respirator recommended for dust, safety goggles, chemical-resistant gloves, lab coat or coveralls
Hygiene Measures: Remove contaminated clothing before leaving work area, wash thoroughly before eating, drinking, or smoking
Appearance: White to off-white crystalline powder
Odor: Odorless or faint, characteristic organic odor
Odor Threshold: Not established
pH: Not determined
Melting Point: 183-187°C
Boiling Point: Decomposes before boiling
Flash Point: Not available
Flammability: Not flammable under normal use
Vapor Pressure: Negligible
Solubility: Slight solubility in water, soluble in organic solvents such as DMSO, ethanol
Density: 1.2–1.3 g/cm³
Partition Coefficient: Not available
Viscosity: Not applicable
Decomposition Temperature: >200°C
Evaporation Rate: Not applicable
Chemical Stability: Stable under normal handling conditions
Conditions to Avoid: Heat, moisture, direct sunlight, dust formation
Reactivity: No hazardous reactivity expected in standard use
Incompatible Materials: Avoid strong oxidizing agents, acids or bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, other unidentified organic compounds
Polymerization: Will not occur
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Oral LD50 (rat) estimated at 500–2000 mg/kg
Skin Corrosion/Irritation: May cause irritation on prolonged exposure
Eye Damage/Irritation: Causes moderate to severe eye irritation
Respiratory Sensitization: Possible with chronic exposure
Skin Sensitization: May trigger allergic reactions
Other Effects: No long-term toxicity studies available
Carcinogenicity/Mutagenicity: Not classified as carcinogen or mutagen by major regulatory bodies
Further Information: Prolonged or repeated exposure may impact liver or kidney based on animal models, handle with care and report unusual symptoms to occupational healthcare staff
Toxicity: Low acute aquatic toxicity expected based on available data, not classified as harmful to aquatic life in low concentrations
Persistence and Degradability: May degrade slowly in environment, low bioaccumulation predicted
Mobility in Soil: May bind to organic content in soil
Bioaccumulation: Not expected to bioaccumulate in aquatic organisms
Other Adverse Effects: Prevent large amounts from contaminating surface or groundwater by following local disposal guidance
Waste Disposal: Incinerate in approved chemical waste facility or landfill according to local, state, and national regulations
Contaminated Packaging: Dispose as hazardous chemical waste, rinse thoroughly before recycling or disposal
Special Precautions: Do not flush in drain, avoid contact with soil and waterways
UN Number: Not regulated for transport
Proper Shipping Name: Chemical, N.O.S. (Not Otherwise Specified)
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Marine Pollutant: No
Special Transport Precautions: Prevent container breakage during transit, secure packaging, carry in tightly closed containers
EU Regulations: Not classified as a hazardous substance under Regulation (EC) No 1272/2008 (CLP)
US Regulations: Not listed under SARA Title III, CERCLA, or TSCA
Other International Regulations: Not listed for major chemical restrictions in Canada, Australia, Japan, or China
Labelling Requirements: Follow local workplace safety laws including hazard communication standards
Workplace Exposure Limits: Not assigned a specific occupational exposure limit
Restriction of Use: For research and manufacturing only, not for human or veterinary drug, food, cosmetic, or household use
