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Product Name: 1,2,5,6-Tetrahydropyridine
Chemical Family: Heterocyclic compound
Molecular Formula: C5H9N
Molecular Weight: 83.13 g/mol
Synonyms: Tetrahydropyridine, Pyridine, 1,2,5,6-tetrahydro-
CAS Number: 504-60-9
Recommended Use: Intermediate for chemical synthesis, research applications
Manufacturer Information: Available from relevant chemical suppliers, research lab providers, contact through supplier website or safety office
Emergency Telephone Number: Refer to institutional or local emergency contact offices
Restrict Use: Not for pharmaceutical, food, or household use
Hazard Classification: Flammable liquid and vapor (Category 3), Acute toxicity – Oral (Category 3), Acute toxicity – Dermal (Category 3), Acute toxicity – Inhalation (Category 2), Skin corrosion/irritation (Category 2), Serious eye damage/eye irritation (Category 2A), Specific target organ toxicity – single exposure (Category 3)
Hazard Statements: Toxic if swallowed, Toxic in contact with skin, Fatal if inhaled, Causes skin irritation, Causes serious eye irritation, Flammable liquid and vapor, May cause drowsiness or dizziness
Signal Word: Danger
Pictograms: Skull and crossbones, exclamation mark, flame, health hazard
Possible Routes of Exposure: Absorption through skin contact, inhalation of vapors, accidental ingestion
Precautionary Statements: Keep away from heat, sparks, open flames, no smoking, avoid breathing vapor, use only outdoors or in a well-ventilated area, wash hands thoroughly after handling, wear protective gloves, protective clothing, eye protection, face protection
Symptoms of Exposure: Nausea, headache, respiratory distress, central nervous system effects, dermal irritation, eye irritation
Other Hazards: May produce hazardous decomposition products in contact with strong oxidizers or acids
Chemical Component: 1,2,5,6-Tetrahydropyridine
Concentration: >98% (typical analytical standard)
CAS Number: 504-60-9
Impurities and Stabilizers: Usually supplied without added stabilizers; impurities less than 2% may include related pyridine derivatives and minor residual solvents
Occupational Exposure Limit: Reference supplier safety documentation for specific permissible exposure limits, as not well established by ACGIH or OSHA
Inhalation: Move victim to fresh air urgently, keep at rest in a position comfortable for breathing, provide artificial respiration if breathing stops, seek immediate medical attention for symptoms such as shortness of breath, coughing, dizziness, neurological changes
Skin Contact: Immediately remove contaminated clothing, flush exposed area with plenty of water for a minimum of 15 minutes, do not attempt to neutralize with chemicals, seek medical attention if irritation, redness, or blistering occurs
Eye Contact: Rinse eyes gently but thoroughly with plenty of water for at least 15 minutes, hold eyelids open, remove contact lenses if wearing, continue rinsing, obtain prompt medical help
Ingestion: Do not induce vomiting unless directed by medical staff, rinse mouth with water, never administer anything by mouth to an unconscious person, seek direct medical care
General Advice: Remove affected individual from source of contamination, ensure access to safety shower and eye-wash stations, present MSDS to attending physician
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam, use water spray to cool fire-exposed containers
Specific Hazards: Flammable vapors may travel considerable distance to ignition sources, emits toxic fumes under combustion (nitrogen oxides, carbon monoxide, carbon dioxide)
Protective Equipment for Firefighters: Positive-pressure self-contained breathing apparatus (SCBA), full protective clothing to prevent all skin and eye contact
Special Procedures: Evacuate area, fight fire from a safe distance, water spray may help prevent fire spread but not effective for extinguishing burning liquid
Explosion Data: Can form explosive mixtures with air at or above flash point, risk of containers rupturing under heat
Personal Precautions: Isolate spill area, keep unprotected persons away, ventilate area, avoid breathing vapors, avoid contact with skin and eyes, remove all ignition sources
Protective Equipment: Suitable chemical-resistant gloves (nitrile, neoprene), splash-proof goggles, lab coat, closed-toe shoes, use appropriate respiratory protection if vapors are present
Spill Clean-up Methods: For small spills, absorb with inert material (vermiculite, sand), collect residue in labeled containers for proper disposal, for larger spills, dike area and collect with explosion-proof equipment
Environmental Precautions: Prevent release into drains, sewers, and waterways, inform relevant authorities if significant spill contaminates environment
Decontamination Procedures: Wash spill area with detergent and water after pickup of material complete
Safe Handling: Work in fume hood or well-ventilated area, avoid physical damage to containers, ground and bond containers during liquid transfer to reduce static discharge risk, use appropriate PPE every time
Storage Conditions: Store in original, tightly closed container, cool, dry, well-ventilated chemical storage room or flammable liquids cabinet, keep away from sources of ignition, incompatible substances (acids, strong oxidizers)
Transfer Precautions: Transfer using dedicated, spark-proof equipment with spill containment
Incompatibilities: Strong acids, strong oxidizers, halogens, sources of heat or direct sunlight
Root Cause Mitigation: Limit quantities open at one time, establish clear labeling and safety signage, restrict access as needed
Engineering Controls: Chemical fume hood, local exhaust ventilation, ensure wash stations and showers nearby
Respiratory Protection: NIOSH/MSHA-approved organic vapor respirator for concentrations above recommended limits, emergency SCBA available
Hand Protection: Nitrile, neoprene, or other chemical-resistant gloves checked for integrity
Eye Protection: Splash-proof goggles with face shield
Skin and Body Protection: Impermeable lab coat, full-length pants, closed-toe chemical-resistant shoes, consider apron depending on task
Hygiene Measures: Wash thoroughly after use before eating, drinking, or using restroom, do not wear contaminated clothing outside of the lab
Exposure Limit Values: Consult local safety office for up-to-date exposure limits, as official thresholds may not exist for this chemical
Appearance: Clear, colorless to light yellow liquid
Odor: Ammonia-like, fishy odor
pH: Not available
Melting Point: -29°C
Boiling Point: 128°C
Flash Point: 23°C (closed cup)
Evaporation Rate: No data
Flammability: Highly flammable liquid and vapor
Explosive Limits: Lower 1.5%, Upper 10.7% (estimated)
Vapor Pressure: 17 mmHg @ 20°C
Vapor Density: 2.9 (air = 1)
Relative Density: 0.87 g/cm³
Solubility: Miscible with most organic solvents, slight solubility in water
Partition Coefficient: No data available
Autoignition Temperature: 335°C
Decomposition Temperature: Not determined
Viscosity: Not determined
Molecular Structure: Six-membered heterocyclic ring, partially saturated pyridine
Chemical Stability: Stable under recommended storage conditions, decomposes on exposure to high heat, light, or incompatible substances
Hazardous Reactions: May react violently with oxidizers or acids
Conditions to Avoid: Open flame, sparks, electrostatic discharge, excessive heat, sunlight, uncontrolled pH
Incompatible Materials: Acids, oxidizing materials, halogens
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, toxic gases under combustion or improper storage
Polymerization: Not likely under normal handling
Routes of Exposure: Skin, eyes, ingestion, inhalation
Acute Toxicity: Oral LD50 (rat) ~68 mg/kg, dermal LD50 (rabbit) ~70 mg/kg, inhalation LC50 (rat, 4hr) ~204 ppm
Chronic Toxicity: Data limited, animal studies suggest neurotoxic effects, potential chronic CNS and respiratory effects
Skin Corrosion/Irritation: May cause moderate to severe irritation
Serious Eye Damage/Irritation: Expected to cause significant irritation
Respiratory Sensitization: Not classified but avoid repeated exposure
Carcinogenicity: Not listed as a known or probable carcinogen by IARC, NTP, OSHA
Reproductive Toxicity: No data indicating reproductive risk, but precaution recommended due to primary CNS effects
Mutagenicity: Not tested, no evidence of mutagenicity in available literature
Medical Conditions Aggravated: Pre-existing skin, eye, or respiratory disorders could be worsened
Aquatic Toxicity: Harmful to aquatic organisms based on structural features and related pyridines
Persistence/Degradability: Readily biodegradable in soil and water under aerobic conditions, breakdown products may include ammonia and nitrates
Bioaccumulative Potential: Potential for bioaccumulation low to moderate; monitor local guidelines for site-specific impacts
Mobility in Soil: Moderate mobility anticipated in most soils due to high water solubility, possible groundwater contamination
Other Adverse Effects: No evidence of significant ozone depleting properties
Special Precautions: Do not allow product to reach ground water, surface water or sewage system in substantial, uncontrolled quantities
Waste Disposal Methods: Collect and dispose via licensed chemical waste disposal contractor, never discharge to environment
Unused Product: Incinerate in an approved facility equipped with afterburner and scrubber
Contaminated Packaging: Container must be triple-rinsed and handled as hazardous waste, comply with all local and national regulations
Disposal Guidance: Adhere to EPA and local environmental protection guidelines, use designated waste streams for flammable organic chemicals
Precautions: Segregate from incompatible materials during interim storage, label containers with full chemical identity, hazard classification, and accumulation start date
UN Number: UN 3286
Proper Shipping Name: Flammable liquid, toxic, n.o.s. (1,2,5,6-Tetrahydropyridine)
Transport Hazard Class: 3 (Flammable liquid), 6.1 (Toxic substance)
Packing Group: II
Special Transport Precautions: Package securely in approved, leak-proof containers, keep away from incompatible goods, emergency response information must accompany all domestic and international shipments
Maritime Pollutant: Consult IMDG code, likely considered marine pollutant for bulk quantities
Air Transport: Regulated under IATA as dangerous goods — passenger aircraft quantity limits apply
TSCA Status: Listed in the U.S. TSCA Inventory
OSHA Hazard Communication: Classified hazardous (flammable liquid, acute toxicity, irritant)
SARA Title III (Sec. 302/311/312/313): Not listed as an extremely hazardous substance; reportable thresholds may require review for on-site quantities
CERCLA Status: No established reportable quantity
California Proposition 65: Not specifically listed, assess risk on case-by-case basis
Canada DSL/NDSL: Listed or may require notification; confirm with supplier
EU Classification: Classified as hazardous under CLP (EC) No 1272/2008
Other Regulations: Responsible parties must review federal, regional, and local rules for workplace, transport, storage and health / environment requirements
Label Elements: Clearly display health, fire, environmental hazard pictograms and precautionary statements on every container
