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Substance Name: 1,2,3,4-Tetrachlorobenzene
Chemical Formula: C6H2Cl4
Common Synonyms: Tetrachlorobenzene, TCB
CAS Number: 634-66-2
Recommended Use: Intermediate in organic synthesis, reference chemical, laboratory reagent
Supplier: [Name, Address, Contact of Supplier]
Emergency Contact Number: [Supplier Emergency Phone]
GHS Classification: Acute Toxicity (Oral) Category 4, Skin Irritation Category 2, Eye Irritation Category 2B, Aquatic Acute Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes eye irritation, toxic to aquatic life
Pictograms: Exclamation mark, Environment
Precautionary Statements: Avoid breathing dust, avoid contact with skin and eyes, prevent release to the environment
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Chemical Name: 1,2,3,4-Tetrachlorobenzene
Concentration: ≥98%
Impurities: Dichlorobenzenes (trace levels), pentachlorobenzene (trace levels)
Other Ingredients: No other additives or stabilizers present
Inhalation: Move to fresh air, monitor for respiratory distress, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, obtain medical attention for irritation
Eye Contact: Flush with water for at least 15 minutes, lift eyelids occasionally, seek medical attention if irritation develops
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical help
Most Important Symptoms: Irritation of respiratory tract, redness or rash on skin, burning sensation in eyes, gastrointestinal symptoms if swallowed
Advice for Emergency Responders: Use personal protective equipment, avoid direct contact, provide symptomatic treatment as needed
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, water spray for large fires
Unsuitable Extinguishing Media: Do not use high pressure water streams
Fire Hazards: Can produce toxic fumes of hydrogen chloride, phosgene, and chlorinated compounds when heated strongly
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Advice for Firefighters: Approach from upwind, avoid breathing fumes, cool containers with flooding quantities of water after fire
Combustion Products: Carbon oxides, hydrogen chloride, chlorinated aromatic compounds
Personal Precautions: Evacuate unnecessary personnel, ventilate area, wear suitable protective equipment including gloves, goggles, protective clothing, and dust mask or respirator
Environmental Precautions: Prevent run-off to drains, surface water, and soil, contain spill with inert materials such as sand or earth
Methods for Clean-Up: Scoop or vacuum spilled material into secure labeled containers for proper disposal, minimize dust generation, dispose of waste according to local regulations
Decontamination: Wash spill area with plenty of water and detergent after removal
Safe Handling: Avoid contact with skin, eyes, and clothing, prevent dust spread, operate under fume hood or with exhaust ventilation, do not eat, drink, or smoke while handling
Storage Requirements: Store in a tightly sealed container in a cool, dry, and well-ventilated place, keep away from heat sources, sunlight, and incompatible materials like strong oxidizers
Protective Measures: Use grounding and bonding for bulk handling, implement spill control procedures, label containers clearly
Storage Class: Chemical storage, hazardous substance section
Exposure Limits: No specific occupational exposure limits established, handle as hazardous chemical
Engineering Controls: Use local exhaust or general ventilation to keep exposure below nuisance levels, work in a chemical fume hood
Personal Protective Equipment: Wear chemical-resistant gloves (nitrile, neoprene), safety goggles or face shield, long-sleeved protective clothing, and suitable respirator for dust
Hygiene Measures: Wash hands after use, do not touch face or eyes with contaminated gloves, keep work clothing separate
Environmental Controls: Prevent accidental release to drainage systems or outdoors
Appearance: White to off-white crystalline powder
Odor: Slight aromatic
Melting Point: 116–119°C
Boiling Point: 262°C
Vapor Pressure: Low (<1 mmHg at room temperature)
Solubility: Insoluble in water, soluble in organic solvents like alcohol, benzene, and ether
Density: Approximately 1.70 g/cm3 at 20°C
pH: Not applicable (insoluble)
Partition Coefficient (log Kow): Estimated around 5.6
Flash Point: Over 100°C (non-flammable under normal conditions)
Chemical Stability: Stable under ordinary conditions, degrades slowly over time with heat and light
Conditions to Avoid: High temperatures, open flame, direct sunlight, generating dust
Incompatible Materials: Strong oxidizing agents, strong acids, bases, reducing agents
Hazardous Decomposition Products: Hydrogen chloride, chlorine, phosgene, carbon oxides
Polymerization: Will not occur
Acute Toxicity: LD50 (oral, rat) ranges from 1,800 to 2,100 mg/kg
Inhalation: Dust can irritate nose and lungs, possible headaches, dizziness, nausea
Skin Contact: May cause redness, irritation or dermatitis after prolonged exposure
Eye Contact: Causes irritation, redness, watering, possible blurred vision
Chronic Effects: Prolonged or repeated exposure may affect liver, kidneys, central nervous system
Carcinogenicity: No concrete evidence for human cancer risk, limited animal testing, not classified by IARC
Mutagenicity/Reproductive Toxicity: Not adequately tested, some structural analogues show these risks
Additional Data: Not listed as a substance of very high concern under REACH; caution based on related chlorinated aromatics’ effects
Ecotoxicity: High toxicity to aquatic organisms, fish LC50 (96h, fathead minnow) around 0.9 mg/L
Persistence and Degradability: Tends to persist in environment, slow biodegradation, resistant to microbial breakdown
Mobility in Soil: Low mobility due to hydrophobic nature, strong adsorption to soil particles
Bioaccumulation: May accumulate in aquatic organisms, potential for food chain biomagnification
Other Adverse Effects: Potential to disrupt aquatic ecosystems, contributes to long-term environmental burden
Disposal Methods: Collect and label waste as hazardous, incinerate at an approved facility with emission controls, avoid landfilling
Contaminated Packaging: Triple rinse containers, puncture and dispose at hazardous waste facility
Legal Requirements: Dispose according to local, regional, and national regulations for hazardous chemical waste
Avoidance: Do not flush into drains, soil, or water systems
Recycling: Not practical due to toxicity and complexity
UN Number: 3077
UN Proper Shipping Name: Environmentally Hazardous Substance, Solid, N.O.S. (contains 1,2,3,4-Tetrachlorobenzene)
Transport Hazard Class: 9 (Miscellaneous Dangerous Substances and Articles)
Packing Group: III
Marine Pollutant: Yes
Special Precautions: Protect packaging from breakage, avoid shipment with food or feed, secure against movement during transit
Labels Required: Environmentally Hazardous Substance, Miscellaneous Dangerous Goods
US TSCA: Listed
EU REACH Status: Not listed as a Substance of Very High Concern
OSHA Status: Hazardous by definition of Hazard Communication Standard
Canada DSL/NDSL: Listed on DSL
WHMIS Classification: D2B (Toxic Material Causing Other Toxic Effects)
Other Regulations: Subject to reporting under SARA Title III, Section 313
Workplace Restrictions: Use in well-ventilated, controlled areas, monitor exposure and health as per occupational safety guidelines
