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Product Name: 1,1,3,3-Tetrachloroacetone
Chemical Formula: C3Cl4O
Synonyms: Tetrachloropropanone
CAS Number: 918-00-3
Recommended Use: Laboratory chemical, industrial manufacturing
Manufacturer/Supplier: Refer to purchasing documentation
Emergency Phone: Local poison control center, local fire department
Email for MSDS Requests: Safety compliance contact from supplier
GHS Classification: Acute toxicity (oral, dermal, inhalation), Skin corrosion/irritation, Eye irritation, Specific target organ toxicity
Signal Word: Danger
Hazard Pictograms: Skull and crossbones, exclamation mark, corrosion
Hazard Statements: Toxic if inhaled or swallowed; causes severe skin burns and eye damage; may cause respiratory irritation
Precautionary Statements: Avoid breathing dust/vapors; wear protective gloves, protective clothing, and eye protection; wash thoroughly after handling; use only in a well-ventilated area
Potential Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms: Cough, shortness of breath, burning sensation, redness, blistering of skin, eye pain, nausea, vomiting
Chemical Name: 1,1,3,3-Tetrachloroacetone
Concentration: 98% or greater
Impurities: May contain traces of related chloro-ketones
Molecular Weight: 197.85 g/mol
EC Number: 213-496-1
Other Components: None relevant for hazard assessment
Inhalation: Move exposed individual to fresh air, monitor breathing, provide oxygen if needed, seek medical attention
Skin Contact: Remove contaminated clothing, rinse skin immediately with water for at least 15 minutes, do not delay seeking medical help
Eye Contact: Rinse eyes cautiously with water for several minutes, remove contact lenses if present, continue rinsing, get urgent medical advice
Ingestion: Rinse mouth, do not induce vomiting, never give anything by mouth to an unconscious person, call medical services immediately
Important Medical Notes: Chemical burns can develop; keep under medical supervision even if symptoms appear mild
Rescue Personnel Protection: Wear chemical-resistant gloves and protective eyewear during response
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam; use water spray to cool containers
Unsuitable Extinguishing Media: Direct water jet may spread chemical
Fire Hazards: Non-flammable but decomposition can release toxic gases such as hydrogen chloride, phosgene, and carbon oxides
Protective Equipment: Full protective clothing and self-contained breathing apparatus
Firefighting Tactics: Stay upwind, avoid breathing fumes, cool containing vessels with water spray, isolate hazard area
Hazardous Combustion Products: Hydrogen chloride, phosgene, carbon monoxide, carbon dioxide
Special Procedures: Do not allow runoff from firefighting to enter drains or watercourses
Personal Precautions: Evacuate unprotected personnel, ventilate area, wear chemical splash suit, gloves, and eye/face protection
Environmental Precautions: Prevent entry into drains, sewers, or natural waterways; notify authorities if large spillage occurs
Methods for Containment: Stop leak if possible without risk; dike spill area by using inert absorbent material such as sand or earth
Cleanup Methods: Collect with chemically resistant tools, place into labeled containers for disposal; decontaminate area by washing with copious water
Decontamination: Neutralize residues with sodium bicarbonate solution then flush with water
Disposal of Collected Material: Arrange for collection by licensed chemical waste disposer
Handling: Handle with sufficient ventilation, use in a chemical fume hood, avoid contact with skin, eyes, clothing; do not inhale vapors or dust; keep away from incompatible substances
Storage: Store in tightly closed containers made of compatible material (glass or HDPE), keep in a dry, cool, well-ventilated location, away from acids, oxidizers, and moisture; avoid exposure to direct sunlight and sources of heat
Special Storage Requirements: Use corrosion-resistant shelving; label clearly; segregate from food and animal feed
Recommended Packaging: Original manufacturer container or approved safety bottle
Incompatibles: Strong alkalis, strong acids, oxidizing agents, reducing agents
Safe Transfer Procedures: Use spill trays; secure containers during transport within facility
Occupational Exposure Limits: No national limit established; minimize exposure as far as possible; use as low as reasonably achievable (ALARA) principles
Engineering Controls: Use chemical fume hood, emergency eyewash, and safety shower in immediate vicinity, local exhaust ventilation
Personal Protective Equipment (PPE): Nitrile or neoprene gloves, chemical splash goggles, face shield, impermeable lab coat or apron
Respiratory Protection: Organic vapor cartridge respirator for incidental exposure, supplied air respirator or SCBA for higher concentrations
Hygiene Measures: Remove soiled clothing immediately, do not eat, drink or smoke during handling, wash hands before breaks and after work, maintain strict personal hygiene
Monitoring of Airborne Levels: Use direct-reading vapor detector meter for chlorinated compounds
Appearance: Clear to slightly yellow liquid
Odor: Pungent, acrid
Odor Threshold: Not determined
pH: Not applicable (neat substance)
Melting Point: Below room temperature
Boiling Point: 149–154 °C
Flash Point: Not easily flammable
Evaporation Rate: Not available
Flammability: Non-flammable
Vapor Pressure: Moderate at room temperature
Vapor Density (air=1): Greater than 1
Specific Gravity: Approximately 1.7
Solubility in Water: Slightly soluble; hydrolyzes slowly
Partition Coefficient (n-octanol/water): Not available
Auto-Ignition Temperature: Not established
Decomposition Temperature: Above boiling point
Viscosity: Low to moderate
Chemical Stability: Stable under normal laboratory and storage conditions
Reactivity: Reacts with water over time with slow hydrolysis; reacts rapidly with strong bases and oxidizers
Conditions to Avoid: Exposure to moisture, high temperatures, open flames, direct sunlight
Materials to Avoid: Alkali metals, amines, strong acids, oxidizers, reducing agents
Hazardous Decomposition Products: Hydrogen chloride gas, phosgene, carbon oxides, other toxic chlorine compounds
Polymerization: Not anticipated under recommended conditions
Other Stability Notes: Product may darken over time due to slow decomposition, but this does not necessarily indicate a significant change in hazard
Exposure Effects: Inhalation—respiratory distress, pulmonary edema, coughing, sore throat; Skin—pain, irritation, possible burns or blisters; Eyes—conjunctivitis, severe irritation, risk of irreversible eye damage; Ingestion—abdominal pain, nausea, vomiting, chemical burns to mouth and throat
Acute Toxicity Values: LD50 (oral, rat): Estimated range 70–200 mg/kg; LD50 (dermal, rabbit): Not determined directly, expected to be low
Chronic Effects: Prolonged or repeated exposure may result in dermatitis, sensitization, possible liver or kidney injury
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Reproductive Toxicity: No specific data
Mutagenicity: Not evaluated in current literature; many chlorinated ketones may raise concern
Sensitization: Potential for skin sensitization
Additional Data: Toxic effects are more severe for children and people with pre-existing respiratory or skin conditions
Ecotoxicity: Highly toxic to aquatic organisms including fish and invertebrates due to hydrolysis to chlorine-containing acids
Persistence and Degradability: May hydrolyze and degrade slowly in aquatic systems, but persistent enough to cause localized damage
Bioaccumulative Potential: Limited evidence available, may not significantly bioaccumulate due to reactivity
Mobility in Soil: Moderate mobility based on molecular characteristics; slowly hydrolyzes into less mobile, acidic substances
Other Adverse Effects: Contaminated water or soil can cause long-term environmental harm; monitor discharges closely
Avoid Release: Efforts should be made to prevent entry into waterways, soil, or groundwater
Waste Disposal: Dispose of in accordance with local, state, and national hazardous waste regulations; specialized incinerator with effluent gas scrubbing preferred
Container Disposal: Rinse empty containers with appropriate solvent, collect washings for disposal, never reuse container for other purposes
Sewage System: Do not discharge into sanitary sewers or storm drains
Waste Management Participants: Work with licensed hazardous waste contractors; keep documentation for regulatory compliance
Spill Remnants: Absorb remaining solution with inert media, place in sealed, labeled hazardous waste containers
Environmental Safeguards: Notify environmental protection authorities if accidental large-scale release threatens the environment
UN Number: UN2810 (Toxic Liquid, Organic, N.O.S. containing tetrachloroacetone)
Proper Shipping Name: Toxic Liquid, Organic, N.O.S. (1,1,3,3-Tetrachloroacetone)
Transport Hazard Class: 6.1 (toxic substances)
Packing Group: II (medium danger)
Label Requirements: Toxic and corrosive warning stickers
Environmental Hazard: Marine pollutant; avoid spillage during transport
Special Transport Notes: Secure upright, segregate from incompatible substances during transit; protect from physical shocks and extreme temperatures
Regulatory Requirements: Comply with international, national, and local transport regulations (ADR, RID, IATA, IMDG)
OSHA Status: Subject to hazardous chemical notification and right-to-know rules
EPCRA Section 302/304/313: Not specifically listed; general reporting required for releases
TSCA Inventory: Listed for industrial and laboratory use
REACH/CLP (Europe): Covered under general laws for hazardous chemicals; notification for use and safety assessment required
WHMIS (Canada): Classified as D1A (very toxic material), E (corrosive material)
International Inventories: Check local country chemical registries for specific status
Labelling: Product containers must carry hazardous chemical labels in accordance with GHS or respective local requirements
Other Regulations: Keep safety data available for all users; provide safety training for exposed workers and emergency personnel
